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Bite MG, Berezenko S, Reed FJ, Derry L: Macrosorb Kieselguhr-agarose composite adsorbents. Appl Biochem Biotechnol. 1988 Aug;18:275-84.
New tools for downstream process design and scale up. Scientific note.. Incompressible Macrosorb composite adsorbents, while retaining all the desirable properties of traditional agarose-based hydrogel media, overcome the operational limitations imposed by the use of soft hydrogels: They permit useful application of fast flow rates without restrictions on bed depth and they can be used in fluidized bed mode. Considerations which are important when contemplating scaled-up processing are discussed. A comparative cost estimate for a production process for extracting albumin from bovine serum in column equipment illustrates the various advantages which may be exploited when using a composite adsorbent in place of a conventional soft gel equivalent. |
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