| 18811174 |
Kawamorita S, Hamasaka G, Ohmiya H, Hara K, Fukuoka A, Sawamura M: Hydrogenation of hindered ketones catalyzed by a silica-supported compact phosphine-Rh system. Org Lett. 2008 Oct 16;10(20):4697-700. Epub 2008 Sep 24.
A heterogeneous mono (phosphine)-Rh catalyst system silica-SMAP-Rh (OMe)(cod), where silica-SMAP stands for a caged, compact trialkylphosphine (SMAP) supported on silica gel, showed broad applicability toward the hydrogenation of hindered ketones. Doubly alpha-branched ketones such as diisopropyl ketone was hydrogenated under nearly atmospheric conditions. Di-tert-butyl ketone could be hydrogenated under more forcing conditions. |
6(0,0,1,1) |