| 15911323 |
Andrade MT, Lima JA, Pinto AC, Rezende CM, Carvalho MP, Epifanio RA: Indole alkaloids from Tabernaemontana australis (Muell. Bioorg Med Chem. 2005 Jun 2;13(12):4092-5.
Arg) Miers that inhibit acetylcholinesterase enzyme.. Ten indole alkaloids from the chloroform extract of stalk of Tabernaemontana australis (Muell. Arg) Miers were tentatively identified by GC-MS, viz., coronaridine (1), voacangine (2), voacangine hydroxyindolenine (3), rupicoline (4), ibogamine (5), ibogaine (6), ibogaline (7), desethyl-voacangine (8), voachalotine (9), and affinisine (10). Of these, the first four were isolated by silica gel open column chromatography, identified by uni- and bidimensional NMR, IR, MS and showed anti-cholinesterasic activity at the same concentration as the reference compounds physostigmine and galanthamine (detection limit of 0.01mM) by TLC assay using the modified Ellman's method. |
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