| 19685748 |
Piao X: [Tyrosinase inhibitor from Angelica dahurica roots] . Zhongguo Zhong Yao Za Zhi. 2009 May;34(9):1117-20.
OBJECTIVE: To isolate and identify the tyrosinase inhibitory constituent from Angelica dahurica. METHOD: A tyrosinase inhibitory constituent was isolated by silica gel column chromatography combined with a bioassay-linked HPLC method. RESULT: An extract of heat-processed A. dahurica roots showed more potent tyrosinase inhibitory activity than that of the crude drug. Tyrosinase inhibitory furanocoumarin, 8-hydroxy-5-methoxypsoralen,was isolated. It express stronger tyrosinase inhibition than the known tyrosinase inhibitor, kojic acid (IC50 = 0.0907 mmol x L (-1)) with IC50 value of 0.0086 mmol x L (-1). Therefore, it is contributive to the increased tyrosinase inhibitory activity of the heat-processed A. dahurica. CONCLUSION: The active constituent was 8-hydroxy-5-methoxypsoralen from the heat-processed A. dahurica. |
87(1,1,1,7) |