| 16252720 |
Li J, Yuan Z: [Biphenyl ferulate from Glehnia littoralis] . Zhong Yao Cai. 2005 Jul;28(7):553-5.
OBJECTIVE: To investigate the prolyl oligopeptidase inhibitory constituents from Glehnia littoralis. METHODS: To determine the prolyl oligopeptidase inhibitory activity in vitro of ethanol extract of G. littoralis and its fractions with Yoshimoto's method, to separate the constituents of the active fractions by repeated silica gel column chromatogrphy. RESULTS: Two ferulate compounds were isolated from EtOAc-soluble fractions of ethanol extract of G. littoralis, which (100 microg/ml) showed mile activity (inhibitory rate: 50%). Compound I, named glehnilate, was a new biphenyl ferulate. Compound II, identified as 2-(4'-hydroxyphenol)-glycol mono trans-ferulate, was isolated from this plant for the first time. Their structures were determined on the basis of their spectral data. |
32(0,1,1,2) |