| 15534068 |
Marshall RC, Powers-Risius P, Reutter BW, O'Neil JP, La Belle M, Huesman RH, VanBrocklin HF: Kinetic analysis of 18F-fluorodihydrorotenone as a deposited myocardial flow tracer: comparison to 201Tl. J Nucl Med. 2004 Nov;45(11):1950-9.
The goals of this investigation were to assess the accuracy of (18) F-fluorodihydrorotenone ((18) F-FDHR) as a new deposited myocardial flow tracer and to compare the results to those for (201) Tl. METHODS: The kinetics of these flow tracers in 22 isolated, erythrocyte- and albumin-perfused rabbit hearts were evaluated over a flow range encountered in patients. The 2 flow tracers plus a vascular reference tracer ((131) I-albumin) were introduced as a bolus through a port just above the aortic cannula. Myocardial extraction, retention, washout, and uptake parameters were computed from the venous outflow curves with the multiple-indicator dilution technique and spectral analysis. RESULTS: The mean +/- SD initial extraction fractions for (18) F-FDHR (0.85 +/- 0.07) and (201) Tl (0.87 +/- 0.05) were not significantly different, although the initial extraction fraction for (18) F-FDHR declined with flow (P < 0.0001), whereas the initial extraction fraction for (201) Tl did not. The washout of (201) Tl was faster (P < 0.001) and more affected by flow (P < 0.05) than was the washout of (18) F-FDHR. Except for the initial extraction fraction, (18) F-FDHR retention was higher (P < 0.001) and less affected by flow (P < 0.05) than was (201) Tl retention. Reflecting its superior retention, the net uptake of (18) F-FDHR was better correlated with flow than was that of (201) Tl at both 1 and 15 min after tracer introduction (P < 0.0001 for both comparisons). CONCLUSION: The superior correlation of (18) F-FDHR uptake with flow indicates that it is a better flow tracer than (201) Tl in the isolated rabbit heart. Compared with the other currently available positron-emitting flow tracers ((82) Rb, (13) N-ammonia, and (15) O-water), (18) F-FDHR has the potential of providing excellent image resolution without the need for an on-site cyclotron. |
2(0,0,0,2) |