| 7680676 |
Meera P, Tripathi O, Kamboj KK, Rao PR: Role of calcium in biphasic immunomodulation by gamma-HCH (lindane) in mice. Immunopharmacol Immunotoxicol. 1993 Jan;15(1):113-29.
gamma-HCH (Lindane) is reported to cause a biphasic immunomodulation-stimulation followed by suppression-after oral administration in mice. Role of calcium in this biphasic immunomodulation was assessed after 4, 12 and 24 wks of gamma-HCH administration. 45Ca-uptake was enhanced during the initial immunostimulation followed by decrease concomitant with immunosuppression. Lymphocyte proliferation was inhibited during both the phases of immune response by verapamil, a calcium channel blocker, and by trifluoperazine, a calmodulin inhibitor. These findings show an impairment of calcium homeostasis in lymphocytes culminating into the biphasic immunomodulatory effects of gamma-HCH. |
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