| 20055685 |
Craver RD, Fonseca P, Carr R: Pediatric epithelial salivary gland tumors: Spectrum of histologies and cytogenetics at a Children's Hospital. Pediatr Dev Pathol. 2010 Jan 7.
Abstract There are conflicting reports regarding the relative frequency of benign and malignant epithelial salivary gland tumors in children. There are only a few reports of the cytogenetic abnormalities in the pleomorphic adenomas (PA) that arise in children, and even less information regarding the pleomorphic adenoma gene 1 (PLAG1) and high motility group A2 (HMGA2 ) histochemical staining in PAs, or their correlation with histologic types (stromal vs epithelial predominance). A retrospective 14 year review of epithelial salivary gland tumors encountered at a children's hospital identified 13 tumors- 12 PAs and 1 acinic cell carcinoma (ACC). No mucoepidermoid carcinomas were identified. Tumors arose in the parotid (7) and other sites (2 submandibular, 4 minor). Ten PAs in our cohort had cytogenetic studies. Four were normal, 5 involved 8q12, and 1 involved 12q13. Immunohistochemistry identified an additional 2 PAs with PLAG1 staining, and 5 additional PAs with HMGA2 staining. One tumor with ins (18;8)(q21.1;q12q22.2) had no PLAG1 staining, but stained with HMGA2. This ins (18;8) may not have involved the PLAG1 gene. There was no demonstrable corrrelation of 8q12/PLAG1 staining or 12q13/HMGA2 staining with histologic type. Thus we found abnormalities in either 8q12/PLAG1 staining or 12q13/HMGA2 staining in all PAs. The HMGA2 staining in 50% of PAs suggests that it may more frequently involved in PAs than previously thought based on cytogenetic studies, at least in children.Key Words: childhood, high motility group protein, pleomorphic adenoma, pleomorphic adenoma gene 1, salivary gland neoplasm. |
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