| 17664321 |
Papagiannitsis CC, Tzouvelekis LS, Tzelepi E, Miriagou V: Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. Antimicrob Agents Chemother. 2007 Oct;51(10):3763-7. Epub 2007 Jul 30.
ACC-4, an omega loop mutant (Val (211)--> Gly) of the Hafnia alvei-derived cephalosporinase ACC-1, was encoded by an Escherichia coli plasmid. The genetic environment of bla (ACC-4) shared similarities with plasmidic regions carrying bla (ACC-1). Kinetics of beta-lactam hydrolysis and levels of resistance to beta-lactams showed that ACC-4 was more effective than ACC-1 against expanded-spectrum cephalosporins. |
4(0,0,0,4) |