| 9403795 |
Krowicki ZK, Hornby PJ: Evidence for a dual mechanism of gastric motor responses to intravenously administered endothelin-1 in anesthetized rats. J Physiol Paris. 1997 May-Oct;91(3-5):203-7.
We have recently reported that endothelin-1 (ET-1), administered intracisternally or microinjected into the DVC of rats, increases gastric motor function via vagal pathways. To determine whether circulating ET-1 acts peripherally or centrally to alter gastric motility, ET-1 (30 and 300 pmol/kg) was administered intravenously in alpha-chloralose anesthetized rats, while monitoring intragastric pressure, gastric motility, heart rate and blood pressure. Endothelin-1, at a dose of 300 pmol/kg, increased intragastric pressure, stimulated pyloric circular muscle contractile activity, and increased arterial pressure. When ET-1 (300 pmol/kg) was administered after bilateral vagotomy at midcervical level, a marked gastric motor inhibition with an increase in arterial blood pressure were observed. We conclude that the gastric motor effects of circulating ET-1 are a result of central excitatory and peripheral inhibitory actions of the peptide. |
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