Protein Information

ID 1321
Name AMPK
Synonyms 5' AMP activated protein kinase subunit beta 1; AMPK; 5' AMP activated protein kinase beta 1 subunit; AMP activated protein kinase beta subunit; AMP activated protein kinase beta 1 non catalytic subunit; AMPK beta 1 chain; AMPK beta1; AMPKb…

Compound Information

ID 1708
Name ACC
CAS 1-aminocyclopropanecarboxylic acid

Reference

PubMed Abstract RScore(About this table)
18614941 Lee-Young RS, Koufogiannis G, Canny BJ, McConell GK: Acute exercise does not cause sustained elevations in AMPK signaling or expression. Med Sci Sports Exerc. 2008 Aug;40(8):1490-4.
PURPOSE: No study has examined the response of skeletal muscle AMP-activated protein kinase (AMPK) signaling beyond the first 3 h after an acute exercise bout in humans. The purpose of this study was to assess AMPK signaling in human skeletal muscle immediately after a single bout of moderate-intensity endurance exercise and 3 and 24 h after the exercise bout. METHODS: We examined AMPK signaling, and protein expression of AMPK alpha, ACC-beta, and nNOS mu in untrained individuals (four females and four males) during the 24-h period after a 60-min bout of moderate-intensity (63 +/- 1% VO2peak) cycling endurance exercise. RESULTS: AMPK alpha2 activity, AMPK alpha2 Thr172 phosphorylation, and ACC-beta Ser222 phosphorylation were increased immediately after exercise. These increases had all returned to basal levels at 3 and 24 h after exercise. Furthermore, an acute bout of exercise did not alter AMPK alpha1, AMPK alpha2, ACC-beta, or nNOS mu protein expression during the 24-h period after exercise. CONCLUSION: Although an acute bout of exercise elicits increases in AMPK signaling, this alone is not sufficient to induce sustained increases in either AMPK signaling or protein expression during the postexercise period.
3(0,0,0,3)