| 2750198 |
Fisher GD, Kilgore WW: Pharmacokinetics of S-[3-chloroprop-2-enyl] glutathione in rats following acute inhalation exposure to 1,3-dichloropropene. Xenobiotica. 1989 Mar;19(3):269-78.
1. An h.p.l.c. method has been developed to quantify the GSH conjugate of 1,3-dichloropropene (DCP). 2. The GSH conjugate of DCP (GSCP) was detected in the blood of rats exposed to DCP by inhalation, and elimination of GSCP from rat blood fitted a one-compartment model. 3. Exposure of rats to 78, 155, or 404 ppm DCP gave an elimination t 1/2 of 17 h, independent of exposure concentration. |
31(0,1,1,1) |