| 11090987 |
Yamazaki M, Mizoguchi H, Ohsawa M, Tseng LF, Suzuki T, Narita M: Implications of Ca (2+)-activated Cl (-) channels in the delta-opioid receptor-mediated antinociception in the mouse spinal cord. Neurosci Lett. 2000 Dec 8;295(3):113-5.
The present study was designed to investigate the role of Ca (2+)-activated Cl (-) channels in the spinal opioid receptor-mediated antinociception using the mouse tail-flick assay. The antinociception induced by intrathecal (i.t.) administration of a selective delta-opioid receptor agonist [D-Ala (2)] deltorphin II (10 microgram, i.t.) was significantly attenuated by i.t.-pretreatment with selective Ca (2+)-activated Cl (-) channel blockers, IAA-94, flufenamic acid and niflumic acid. By contrast, IAA-94 had no effect on the antinociception induced by i.t.-treated with either the selective mu-opioid receptor agonist [D-Ala (2),N-MePhe (4), Gly-ol (5)] enkephalin or the kappa-opioid receptor agonist U-50,488H. The present results provide evidence for the first time that the Ca (2+)-activated Cl (-) channel is, at least in part, implicated in the delta-, but not the mu- and kappa-opioid receptor-mediated antinociception in the mouse spinal cord. |
32(0,1,1,2) |