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Yamada H, Uchigata Y, Kawasaki E, Matsuura N, Otani T, Sato A, Mutoh K, Kasahara T, Fukushima N, Koike A, Mizota M, Miura J, Kubo H, Yamaguchi A, Nagataki S, Omori Y, Iwamoto Y: Onset age-dependent variations of three islet specific autoantibodies in Japanese IDDM patients. Diabetes Res Clin Pract. 1998 Mar;39(3):211-7.
The age related incidence rate of insulin-dependent diabetes mellitus shows a bimodal distribution, not only in Caucasians but also in Japanese. To evaluate the onset age-related autoimmune profile at presentation in insulin-dependent diabetes mellitus (IDDM), glutamic acid decarboxylase (GAD) autoantibody, islet cell antibody (ICA), and insulin autoantibody (IAA) were measured in 137 newly diagnosed Japanese IDDM patients with onset ages between 0-29 years. The prevalence of GAD autoantibody was significantly increased from the lowest (32%) in the 0-5 years onset age group to 75% in the 13-19 years onset age group (P < 0.05), whereas the IAA prevalence significantly decreased from the peak (48%) in the 6-12 years onset age group to 10% in the 20-29 years onset age group (P < 0.05). The ICA prevalence was increased from the lowest (32%) in the 0-5 years onset age group to the highest (53%) in the 20-29 years onset age group similar to that for the GAD autoantibody. Such results demonstrate that there was age-related autoimmune characteristics at presentation of IDDM in Japanese as well as in Caucasians. |
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