| 17294044 |
Fu ZY, DU CY, Yao Y, Liu CW, Tian YT, He BJ, Zhang T, Yang Z: [Effects of beta-cypermethrin on voltage-gated potassium channels in rat hippocampal CA3 neurons]. Sheng Li Xue Bao. 2007 Feb 25;59(1):63-70.
The effects of beta-cypermethrin (consisting of alpha-cypermethrin and theta-cypermethrin) on the transient outward potassium current (I (A)) and delayed rectifier potassium current (I (K)) in freshly dissociated hippocampal CA3 neurons of rats were studied using whole-cell patch-clamp technique. The results indicated that alpha-cypermethrin increased the value of I (A) and theta-cypermethrin decreased the value of I (A), though both of them shifted steady activation curve of I (A) towards negative potential. theta-cypermethrin contributed to the inactivation of I (A). The results also showed that alpha-cypermethrin and theta-cypermethrin decreased the value of I (K), and shifted the steady state activation curve of I (K) towards negative potential. Both alpha-cypermethrin and theta-cypermethrin had no obvious effects on the inactivation of I (K). theta-cypermethrin prolonged recovery process of I (K). These results imply that both transient outward potassium channels and delayed rectified potassium channels are the targets of beta-cypermethrin, which may explain the mechanism of toxical effects of beta-cypermethrin on mammalian neurons. |
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