| ID | 77 |
|---|---|
| Name | brains |
| Synonyms | BPG dependent PGAM 1; Brain; CDABP0006; PGAM 1; PGAM B; PGAM1; PGAM1 protein; PGAMA… |
| ID | 183 |
|---|---|
| Name | lindane |
| CAS | (1α,2α,3β,4α,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 18695515 | Mao H, Liu B: Synergistic microglial reactive species generation induced by pesticides lindane and dieldrin. Neuroreport. 2008 Aug 27;19(13):1317-20. Elevated environmental exposure to pesticides is a known risk factor to the development of sporadic Parkinson's disease resulting from the degeneration of nigral neurons. Among the suspected agents are the highly persistent and bioaccumulative organochlorinated pesticides (OCPs). We report here that lindane and dieldrin, two widely present OCPs that are found enriched in the nigra of postmortem Parkinson's disease brains synergistically induced the production of reactive species (ROS) in microglia. Inhibitor studies indicated that the lindane and dieldrin-induced ROS generation was mediated by oxidase. As microglial ROS is a key contributor to the degeneration of the oxidative damage-vulnerable neurons, our findings shed significant light on the role of OCPs in the development of Parkinson's disease. |
31(0,1,1,1) |