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Ibricevic H, Heyeraas KJ, Pasic Juhas E, Hamamdzic M, Djordjevic N, Krnic J: Identification of alpha 2 adrenoceptors in the blood vessels of the dental pulp. Int Endod J. 1991 Nov;24(6):279-89.
Using selective agonists and antagonists of alpha2 adrenoceptors, attempts were made to identify the subtype alpha2 adrenoceptors in the blood vessels of the canine dental pulp. In chloralose-anaesthetized dogs, intra-arterial administration of noradrenaline and guanabenz in different doses produced a dose-related pulpal vasoconstriction which was measured using hydrogen-gas clearance. The vasoconstrictor response to noradrenaline was inhibited by phentolamine, a non-selective alpha adrenoceptor antagonist. The response to guanabenz was inhibited by rauwolscine, a highly selective alpha2 adrenoceptor antagonist. The results demonstrated that alpha2 adrenoceptors are present in the blood vessels of dog dental pulp. |
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