| 18817401 |
Traff A, Bogar K, Warner M, Backvall JE: Highly efficient route for enantioselective preparation of chlorohydrins via dynamic kinetic resolution. Org Lett. 2008 Nov 6;10(21):4807-10. Epub 2008 Sep 26.
Dynamic kinetic resolution (DKR) of various aromatic chlorohydrins with the use of Pseudomonas cepacia lipase (PS-C "Amano" II) and ruthenium catalyst 1 afforded chlorohydrin acetates in high yields and high enantiomeric excesses. These optically pure chlorohydrin acetates are useful synthetic intermediates and can be transformed to a range of important chiral compounds. |
1(0,0,0,1) |