| 8042972 |
Dey R, Datta SC: Leishmanial glycosomes contain superoxide dismutase. . Biochem J. 1994 Jul 15;301 ( Pt 2):317-9.
In this work we report that superoxide dismutase is entrapped in a microbody-like organelle, the glycosome, present in Leishmania spp. Studies on the sensitivity of the enzyme to various inhibitors indicated that glycosomal superoxide dismutase is predominantly of the Cu/Zu type. Localization of superoxide dismutase in glycosomes points to the major importance of this organelle in the survival of this pathogen, suggesting a new approach towards chemotherapy for leishmaniasis. |
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