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Shasby DM, Shasby SS: Active transendothelial transport of albumin. Circ Res. 1985 Dec;57(6):903-8. Interstitium to lumen. . Cultured porcine pulmonary artery endothelial monolayers actively transport albumin from interstitium to lumen. The active process favors interstitial to luminal transport by a factor of 10 even in the face of a 2:1 luminal:interstitial albumin gradient. The active process is abolished by treatment with 1 mM sodium cyanide. Dextran is not actively transported. This process could be important in determining transvascular fluid balance and transfer of macromolecules across the endothelium. |
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