| 17846709 |
Lixia G, Fei Y, Jiajia J, Jianhui L: Triethylene tetramine, a novel ligand of G-quadruplex, induces senescence of MCF-7 cells. Biotechnol Lett. 2008 Jan;30(1):47-53. Epub 2007 Sep 6.
Interference with telomerase and telomere maintenance is emerging as an attractive target for antitumor therapies. Ligands stabilizing G-quadruplexes have the potential to interfere with telomere replication by blocking the elongation of telomeres in tumors. Here, we report that long-term treatment with triethylene tetramine (TETA), at 50 or 100 microM, induced marked cellular senescence phenotypes accompanied by increased time of population doubling of MCF-7 cells. Cyclin-dependent kinase inhibitors, including p53 and p21, were also upregulated in TETA-treated MCF-7 cells. TETA is therefore as novel ligand of G-quadruplex and can induce tumor senescence; it is a promising material for tumor treatment. |
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