| 6479106 |
Ater SB, Swinyard EA, Tolman KG, Franklin MR: Anticonvulsant activity and neurotoxicity of piperonyl butoxide in mice. Epilepsia. 1984 Oct;25(5):551-5.
Piperonyl butoxide, a microsomal monooxygenase inhibitor, administered intraperitoneally to mice exerts peak anti-maximal electroshock activity and peak neurotoxicity at 5 and 7h, respectively. The median neurotoxic dose is 1,690 mg/kg. In the maximal electroshock seizure test, the median effective dose (ED50) is 457 mg/kg and the protective index (PI) is 3.69. In the subcutaneous pentylenetetrazol test, the ED50 is 443 mg/kg and the PI is 3.81. Piperonyl butoxide prevents seizure spread and elevates seizure threshold. Its PI compares favorably with PIs of clinically useful anticonvulsants. |
31(0,1,1,1) |