| 4011323 |
Vanden Bossche H: How anthelmintics help us to understand helminths. Parasitology. 1985 Apr;90 ( Pt 4):675-85.
Study of the mode of action of the anti-parasitic 'hydrogenophore', closantel, revealed that mitochondria isolated from livers of untreated rats, 13 weeks after infection with Fasciola hepatica metacercariae, were uncoupled. This uncoupling of mitochondria might be induced by a product (s) excreted by the liver fluke. The lipid extractable product (s) binds to albumin and has a molecular weight between 500 and 1000 Daltons. A second unexpected finding indicates that closantel affects the motility of Schistosoma mansoni in vitro by interfering with mitochondrial ATP synthesis. The results obtained are suggestive of a role for aerobic metabolism in the generation of energy required for motility. |
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