| 2444176 |
Begum SJ, Reddy MM, Indira K, Swami KS: Effect of dieldrin on catalytic potential of field mouse Mus booduga brain acetylcholinesterase. Arch Int Physiol Biochim. 1987 Jun;95(2):101-4.
Substrate kinetics of acetylcholinesterase (AChE) were investigated in control and dieldrin-treated Mus booduga brains. Non competitive inhibition with respect to activation by acetylcholine was indicated by decreased maximal velocity (V) without change in Michaelis-Menten constant (Km). Activation energies (delta E) were found to be increased suggesting decreased efficiency of enzyme in dieldrin-treated mouse brains. Fall in the activity potential of AChE may account for the interference of dieldrin or its metabolites with the acetylcholine (ACh)--AChE system and deserve consideration in contributing to the neurotoxicity. |
112(1,2,2,2) |