| 7117752 |
Kurata M, Hirose K, Umeda M: Inhibition of metabolic cooperation in Chinese hamster cells by organochlorine pesticides. Gann. 1982 Apr;73(2):217-21.
Effects of organochlorine pesticides on the metabolic cooperation in the hypoxanthine-guanine-phosphoribosyl-transferase system using wild-type 6-thioguanine-sensitive V79 cells and variant 6-thioguanine-resistant cells were surveyed. The metabolic cooperation was inhibited by 1,1,1-trichloro-2,2-bis (p-chlorophenyl) ethane (DDT), 1,1-dichloro-2,2-bis (p-chlorophenyl) ethane (TDE), 1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl) ethane (o,p'-DDT), 1,1,1-trichloro-2,2-bis (p-methoxyphenyl) ethane (methoxychlor), aldrin, dieldrin, endrin, heptachlor, alpha-isomer of benzene hexachloride (alpha-BHC), and gamma-BHC, but not beta-BHC. The present results suggest that the pesticides which inhibited the metabolic cooperation may be tumor promoters. |
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