| 2806169 |
Reddy GR, Babu GR, Reddanna P, Chetty CS: Substrate-affinity relationship of succinate dehydrogenase in brain of albino rat during dieldrin toxicity. Ecotoxicol Environ Saf. 1989 Oct;18(2):141-4.
Substrate kinetics of succinate dehydrogenase (EC 1.3.99.1) were studied in the brain of control and dieldrin-treated albino rats. Dieldrin inhibited the enzyme activity to various degrees and also altered the Michaelis-Menten constant (Km) of the enzyme. Activation energy values (delta E) were increased, suggesting decreased maximal velocity Vmax, and the high Km obtained for the enzyme also revealed decreased enzyme-substrate affinity and masking of active sites by dieldrin. |
62(0,2,2,2) |