| 12688530 |
Kalavrizioti D, Vourekas A, Tekos A, Tsagla A, Stathopoulos C, Drainas D: Kinetics of inhibition of ribonuclease P activity by peptidyltransferase inhibitors. Mol Biol Rep. 2003 Mar;30(1):9-14.
Effect of antibiotics on RNase P.. A cell-free system derived from Dictyostelium discoideum has been used to study the kinetics of inhibition of RNase P by puromycin, amicetin and blasticidin S. Detailed kinetic analysis showed that the type of inhibition of RNase P activity by puromycin is simple competitive, whereas the type of inhibition by amicetin and blasticidin S is simple non-competitive. On the basis of Ki values amicetin is stronger inhibitor than puromycin and blasticidin S. |
113(1,2,2,3) |