| 6801818 |
Cambon C, Fernandez Y, Falzon M, Mitjavila S: Variations of the digestive absorption kinetics of carbaryl with the nature of the vehicle. Toxicology. 1981;22(1):45-51.
Blood kinetics of 1-naphthyl-N-methyl [14C] carbamate were determined after intravenous injection in DMSO, and after intragastric and intraduodenal administration in DMSO, oil, gum tragacanth and milk. The acetylcholinesterase inhibition and the level of 14C-activity were both determined in the blood over various periods of time. The values of the absorption rate constants after intragastric and intraduodenal administration were found to be: 0.5 h (-1) and 7 h (-1) with DMSO, 0.6 h (-1) and 0.42 h (-1) with oil, 0.13 h (-1) and 0.22 h (-1) with gum tragacanth and 0.10 h (-1) with milk. Appearance of the toxic effect (the inhibition of the acetylcholinesterases) was closely related to the absorption rate constants which themselves depend on the administration vehicle employed. |
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