| 1609493 |
Abdul Awal M: The influence of single topical application of dichlorvos on blood esterases and toxicity in male calves. Vet Hum Toxicol. 1992 Jun;34(3):229-31.
The effect of dichlorvos on inducing changes in blood esterase activities and systemic toxicity was investigated following single topical applications of 1, 3 or 6% dichlorvos concentrations to male calves. Dichlorvos at 1% concentration did not produce any signs of toxicity, whereas 3 and 6% concentrations induced mild to severe toxicity characteristic of anticholinesterase poisoning. Dichlorvos at all concentrations significantly inhibited erythrocyte cholinesterase (25-75%), plasma cholinesterase (30-85%), and serum carboxylesterase (15-51%) activities in male calves. The dose-dependent inhibition was maximum 12 h after insecticide exposure. The extent of inactivation of blood esterases was not correlated with the severity of toxicity. Inhibition of blood cholinesterases by the 6% dichlorvos was still present 21 d after the dichlorvos exposure. |
162(2,2,2,2) |