| 19116254 |
Han JY, Miller SA, Wolfe TM, Pourhassan H, Jerome KR: Cell type-specific induction and inhibition of apoptosis by Herpes Simplex virus type 2 ICP10. J Virol. 2009 Mar;83(6):2765-9. Epub 2008 Dec 30.
Herpes simplex virus (HSV) inhibits apoptosis induced by external stimuli in epithelial cells. In contrast, apoptosis is the primary outcome in HSV-infected lymphocytes. Here, we show that HSV type 2 (HSV-2) gene expression appears to be necessary for the induction of apoptosis in Jurkat cells, a T-cell leukemia line. HSV-2 ICP10 gene expression is sufficient to induce apoptosis in Jurkat cells, while its expression protects epithelial HEp-2 cells from apoptosis triggered by cycloheximide and tumor necrosis factor alpha. Thus, the effect of HSV-2 gene expression on the cellular apoptotic pathway appears to depend on the specific cell type. |
31(0,1,1,1) |