| 10889461 |
Said SI, Pakbaz H, Berisha HI, Raza S: NMDA receptor activation: critical role in oxidant tissue injury. Free Radic Biol Med. 2000 Apr 15;28(8):1300-2.
The excitatory amino acid glutamate serves important neurologic functions, but overactivation of its N-methyl-D-aspartate (NMDA) receptor is toxic to neurons (excitotoxicity). We report that NMDA receptor blocker MK-801 (dizocilpine maleate) attenuated oxidant injury induced by paraquat or by xanthine oxidase. We conclude that excitotoxicity may be a key factor in oxidant tissue injury. |
6(0,0,1,1) |