| 18344105 |
Hantson P, Bernard A, Hermans C: Kinetics and determinants of the changes of CC16, a lung secretory protein in a rat model of toxic lung injury. Clin Toxicol. 2008 Mar;46(3):230-8.
PURPOSE: To investigate the kinetics and the determinants of the changes of the Clara cell 16 kDa protein (CC16) as a marker of lung injury following exposure to different toxicants. METHODS: Rats were treated with 4-Ipomeanol (IPO), alpha-naphtylthiourea (ANTU), sodium chromate (Na (2) CrO (4)) or paraquat-(PQ). The changes of CC16, total protein, albumin, and cystatin-C were determined on BALF supernatan, and CC16, cystatin-C and creatinine levels were also determined in serum. RESULTS: Bronchiolar insult due to IPO or ANTU resulted in an initial transient increase of serum CC16, parallel to that of albumin in BALF, and a subsequent reduction in both BALF and serum. A slight reduction of CC16 in BALF was already apparent one hour following treatment with PQ. In the serum, CC16 increased to 400% of basal value. With PQ and Na (2) CrO (4), the elevation of CC16 was mainly determined by the degree of renal impairment. |
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