| 9175510 |
Chang MJ, Chen YC, Yang HJ: Comparative evaluation on the biological monitoring of exposure to parathion and its methyl analog. Arch Environ Contam Toxicol. 1997 May;32(4):422-5.
The effects of both parathion and methyl parathion on the inhibition of plasma cholinesterase were elaborated in a rat model employing a modified isocratic reverse-phase HPLC method coupled with UV detection for the determination of the urinary metabolite p-nitrophenol (U-4NP). A linearity of r2 > 0.995 was found for a standard curve ranging from 0.06 to 0.96 microg/mL with a % relative error of parathion and methyl parathion for both the percent inhibiton of cholinesterase as well as the urinary elimination of 4NP. It is tentatively recommended that an U-4NP of 2. 0 mg/g creatinine be established as a biological exposure index (BEI) for methyl parathion. |
87(1,1,2,2) |