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Larsen KO, Hanel HK: Effect of exposure to organophosphorus compounds on S-cholinesterase in workers removing poisonous depots. Scand J Work Environ Health. 1982 Sep;8(3):222-6.
Biological monitoring and the control of safety precautions against organophosphorus compounds (parathion, malathion, and methylparathion) was performed through the measurement of S-cholinesterase (E.C.3.1.1.8) in personnel removing poisonous depots. Depressions in S-cholinesterase activity where found in a majority of 62 workers in comparison to their preexposure values. After the last exposure the S-cholinesterase activity of the workers returned to the individual preexposure values; a few individuals needed about half a year for their S-cholinesterase activity to reach the preexposure level. As no workers showed either pathological values for the enzyme or poisoning symptoms, it was concluded that the measurement of S-cholinesterase activity is an adequate and sensitive method for monitoring and controlling exposure to organophosphorus compounds. |
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