| 10896051 |
Jahng Y, Park JG, Yoo JW, Kim SY, Kim T, Yang JH: Synthesis and biological activity of conformationally controlled 2-PAM derivatives. Arch Pharm Res. 2000 Jun;23(3):222-5.
A series of conformationally controlled 2-PAM derivatives were prepared from 2-acetylpyridine and 2,3-pyrido [b] cycloalkenones in two steps and their reactivities towards parathion poisoned AChE were evaluated. The most planar 2,3-pyrido [b] cyclohexanone oxime methiodide showed an activity comparable to 2-PAM implying E-syn is that the most active conformation of 2-PAM in the biological system. |
31(0,1,1,1) |