| 3008132 |
Pawlowska D, Moniuszko-Jakoniuk J, Soltys M: The effect of chronic physical exercise on the activity of hydrolytic enzymes in acute poisoning with parathion-methyl in rats. Pol J Pharmacol Pharm. 1985 Sep-Oct;37(5):639-46.
Parathion-methyl, 10 mg/kg p.o., was given to unexercised rats, rats trained for 3 weeks and resting for 2 days, and trained rats subjected to a single physical exercise before treatment. The activity of cholinesterase (ChE) in the serum, of paraoxonase--in the serum and liver, and of beta-glucuronidase (beta-gluc)--in the serum, liver and intestine were determined 1 h after the treatment. Repeated physical exercise increased beta-gluc activity in the serum and liver and inhibited it in the intestine, while a single race after repeated exercise inhibited paraoxonase activity in the serum. Parathion-methyl inhibited ChE and paraoxonase activities and an increased beta-gluc activity in the serum. Repeated physical exercise and a single race, applied 2 days after the end of training, affects the activity of parathion-methyl in a significant yet diversified manner, dependent upon the examined biochemical parameters. |
1(0,0,0,1) |