| ID | 715 |
|---|---|
| Name | p47phox |
| Synonyms | 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NCF 1; NCF 47K; NCF1; NCF1A; NOXO 2; NOXO2… |
| ID | 309 |
|---|---|
| Name | sulfur |
| CAS | sulfur |
| PubMed | Abstract | RScore(About this table) |
|---|---|---|
| 20035290 | Abe H, Liu G, Chi H, He W, Kitaoka N, Yamashita K, Kodama H: Effects of sulfur amino acids on tyrosyl or serine/ phosphorylation and translocation of cytosolic compounds to cell membrane in stimulus-treated human neutrophils. Acta Med Okayama. 2009 Dec;63(6):339-48. We investigated the effects of various sulfur amino acids on the phosphorylation of proteins and the translocation of cytosolic compounds to cell membrane in stimulus-treated human neutrophils using specific monoclonal antibodies. D,L- and D,L- enhanced fMLP-induced tyrosyl phosphorylation of proteins and the translocation of p47phox, p67phox, and rac to the cell membrane in a concentration-dependent manner. NAc- and carboxymethylcysteine suppressed the tyrosyl phophorylation and translocation of cytosolic compounds to the cell membrane. and NAc- suppressed PMA-induced serine/ phosphorylation and the translocation of cytosolic compounds to the cell membrane. NAc- and D,L- enhanced AA-induced serine/ phosphorylation and the translocation of cytosolic compounds to the cell membrane, but had opposite effects. These results indicated that the effects of sulfur amino acids on tyrosyl or serine/ phosphorylation and the translocation of p47phox, p67phox, and rac to the cell membrane in the stimulus-treated human neutrophils were in parallel with those of the stimulus-induced generation reported in previous paper. D,L- and weakly inhibited lipid peroxidation, but the other sulfur amino acids tested had no effect. |
82(1,1,1,2) |