| 18492750 |
Romagnoli E, Mascia ML, Cipriani C, Fassino V, Mazzei F, D'Erasmo E, Carnevale V, Scillitani A, Minisola S: Short and long-term variations in serum calciotropic hormones after a single very large dose of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) in the elderly. J Clin Endocrinol Metab. 2008 Aug;93(8):3015-20. Epub 2008 May 20.
CONTEXT: In humans, few studies have compared the potencies of ergocalciferol and cholecalciferol in improving and maintaining vitamin D status. OBJECTIVE: Our objective was to evaluate the effects of a single very large dose of both calciferols on serum changes of 25-hydroxyvitamin D [25 (OH) D], 1,25-dihydroxyvitamin D [1,25 (OH)(2) D], ionized calcium, and parathyroid hormone (PTH) at baseline, and at 3, 7, 30, and 60 d. DESIGN: This was a prospective randomized intervention study. SETTING: The study was performed in a nursing home residence. PARTICIPANTS: A total of 32 elderly female patients (age range 66-97 yr), with vitamin D deficiency was included in the study. INTERVENTION: Participants were randomized into four groups of eight to receive a single dose of 300,000 IU ergocalciferol or cholecalciferol by oral (os) or im route. RESULTS: 25 (OH) D levels sharply increased at d 3 only when vitamins were given os. The 30-d basal difference in serum 25 (OH) D was significantly greater after cholecalciferol os administration (47.8 +/- 7.3 ng/ml) compared with other forms (D (3) im: 15.9 +/- 11.3; D (2) os: 17.3 +/- 4.7; D (2) im: 5 +/- 4.4; all P < 0.001). The area under the curve (AUC) of the serum 25 (OH) D against time (AUC (60)) was: D (3) os, 3193 +/- 759 ng x d/ml vs. D (2) os, 1820 +/- 512, P < 0.001; and D (3) im, 1361 +/- 492 vs. D (2) im, 728 +/- 195, P < 0.01. 25 (OH) D significantly influences PTH levels at 3 (P < 0.03), 7 (P < 0.01), 30 (P < 0.01), and 60 d (P < 0.05). At 60 d, the form of vitamin (cholecalciferol) significantly lowers PTH levels (P = 0.037). CONCLUSIONS: Cholecalciferol is almost twice as potent as ergocalciferol in increasing serum 25 (OH) D, when administered either by mouth or im. 25 (OH) D plays a role in modulating serum PTH. |
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