| 20191298 |
Kimura H: Hydrogen sulfide: its production, release and functions. . Amino Acids. 2010 Feb 27.
Hydrogen sulfide (H (2) S), which is a well-known toxic gas, has been recognized as a signal molecule as well as a cytoprotectant. It is produced by three enzymes, cystathionine beta-synthase, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase along with cysteine aminotransferase. In addition to an immediate release of H (2) S from producing enzymes, it can be stored as bound sulfane sulfur, which may release H (2) S in response to physiological stimuli. As a signal molecule, it modulates neuronal transmission, relaxes smooth muscle, regulates release of insulin and is involved in inflammation. Because of its reputation as a toxic gas, the function as a cytoprotectant has been overlooked: the nervous system and cardiovascular system are protected from oxidative stress. In this review, enzymatic production, release mechanism and functions of H (2) S are focused on. |
1(0,0,0,1) |