| 856330 |
Kokshareva NV, Kovtun SD, Kagan IuS, Miziukova IG, Medvedev BM: [Effect of a new cholinesterase reactivator, diethixime, on the central nervous system]. Biull Eksp Biol Med. 1977 Jan;83(1):29-32.
A new cholinesteras reactivator--chlorohydrate of S-diethylaminoethyl ether p-bromo benzoylthiohydroxime acid (diethixime), containing a tertiary nitrogen atom in the molecule, was shown to produce a central effect in a dose of 20 mg/kg--1/50 LD50--in contrast to diproxime in a dose of 3 mg/kg, containing a quarternary nitrogen atom, under intoxication of albino rats and rabbits with dimethyl-dichlorynylphosphate. This effect was confirmed by the restortion of the cholinesterase activity in different parts of the rabbit brain, by the normalization of the EEGand of the functional stateof motor neurons of the rat spinal cord. |
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