| 17064049 |
Uozumi Y, Suzuka T: pi-Allylic C1-substitution in water with nitromethane using amphiphilic resin-supported palladium complexes. J Org Chem. 2006 Oct 27;71(22):8644-6.
Nitromethane was safely applied as a C1 nucleophile for palladium-catalyzed pi-allylic substitution in water with amphiphilic PS-PEG resin-supported phosphine-palladium complexes. Catalytic asymmetric nitromethylation of cycloalkenyl esters was achieved in water as a single reaction medium under heterogeneous conditions using 5 mol % palladium of a PS-PEG resin-supported palladium-imidazoindolephosphine complex to give optically active (cycloalkenyl) nitromethanes with up to 98% ee. |
31(0,1,1,1) |