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Wongtrakul J, Wongsantichon J, Vararattanavech A, Leelapat P, Prapanthadara LA, Ketterman AJ: Molecular cloning and expression of several new Anopheles cracens epsilon class glutathione transferases. Protein Pept Lett. 2009;16(1):75-81.
Glutathione transferases, GSTs, are detoxification proteins that are found in most organisms. The acGSTE3-3 had the ability to conjugate 4-hydroxynonenal, a cytotoxic lipid peroxidation product. Although other Epsilon GSTs showed roles in insecticide metabolism, the acGSTE3-3 appeared to have a major role in detoxifying lipid peroxidation products conferring protection against oxidative damage. |
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