| 18577696 |
Lam CK, Chari M, Wang PY, Lam TK: Central lactate metabolism regulates food intake. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E491-6. Epub 2008 Jun 24.
The central nervous system regulates food intake (FI) and body weight (BW), but the associated mechanisms remain to be elucidated. Here we report that central injections of lactate reduced FI and BW in rodents. Inhibition of central lactate metabolism to pyruvate with the lactate dehydrogenase inhibitor oxamate abolished the central effects of lactate on FI and BW. Conversely, central injections of pyruvate recapitulated the effects of lactate. Finally, inhibition of central lactate metabolism prevented the ability of circulating lactate to lower FI and BW. Together, the data indicate that activation of central lactate metabolism lowers FI and BW. |
31(0,1,1,1) |