| 9159868 |
Bozhkov AI: Three dose-dependent stages of the effect of copper ions on functional activity of biological systems. Biochemistry. 1997 Feb;62(2):149-57.
The dose-dependent effects of copper sulfate on the proliferation and functional activity of the genome of liver cells and of algae in vivo and the activity of RNA-polymerase and glucose-6-phosphatase and formation of malonic dialdehyde in vitro were investigated. Administration of various doses of copper sulfate causes a dose-dependent three-phase response of biological systems comprising a stimulation phase, a latent phase, and a phase of inhibition. The degree of manifestation of the three-phase response depends on the functional activity of the biological system. The consecutive dose-dependent binding of metal ions with components of cells forms the basis of the three-phase response to copper ions. |
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