Protein Information

ID 37
Name ceruloplasmin
Synonyms CP; CP protein; Ceruloplasmin; Ceruloplasmin precursor; Ferroxidase; ceruloplasmin (ferroxidase); CP; CP proteins…

Compound Information

ID 314
Name copper sulfate
CAS sulfuric acid copper(2+) salt (1:1)

Reference

PubMed Abstract RScore(About this table)
8923258 Du Z, Hemken RW, Harmon RJ: Copper metabolism of holstein and jersey cows and heifers fed diets high in cupric sulfate or copper proteinate. J Dairy Sci. 1996 Oct;79(10):1873-80.
Eight Holstein and 8 Jersey primiparous cows (3 d postcalving) and 8 Holstein and 8 Jersey growing heifers were randomly assigned to 1 of 8 treatments in a 2 x 2 x 2 factorial arrangement to compare Cu metabolism between Holsteins and Jerseys and the bioavailabilities of Cu in Cu proteinate and CuSO4. The variables were Holstein or Jersey, Cu supplementation at 5 or 80 mg/kg of DM, and supplements of CuSO4 or Cu proteinate. Jerseys had higher hepatic Cu concentrations than did Holsteins on d 60 (346 vs. 303 micrograms/g of DM). At the high Cu supplementation, hepatic Cu increased more rapidly, and content was higher in Jerseys than in Holsteins by d 60 (520 vs. 439 micrograms/g of DM). On d 0, plasma Cu concentrations were 0.99 and 0.80 microgram/ml, and, on d 60, concentrations were 0.96 and 0.88 microgram/ml for Jerseys and Holsteins, respectively. Overall, serum ceruloplasmin oxidase activity was greater for Jerseys than for Holsteins. Jersey cows and heifers also had greater hepatic Fe (208 vs. 173 micrograms/g of DM) and lower hepatic Zn (82 vs. 91 micrograms/g of DM) than did Holstein cows and heifers at d 60. The bioavailability of Cu in Cu proteinate and CuSO4 was the same. Plasma Cu concentration and ceruloplasmin have limited value as indicators of Cu status and availability to dairy cows and heifers.
2(0,0,0,2)