| 2975107 |
Lipsky PE: Suggested mode of action of D-penicillamine as an immunosuppressive agent in rheumatoid arthritis. Z Rheumatol. 1988;47 Suppl 1:6-8.
The mechanism by which D-Penicillamine is effective in the treatment of rheumatoid arthritis has been investigated. The results indicate that D-Penicillamine in synergism with copper or ceruloplasmin in vitro inhibits the proliferation of T-lymphocytes and the activity of helper T-cells in supporting the generation of antibody-forming cells. This effect is mediated by the production of H2O2. The significance of these findings for in vivo processes is discussed. |
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