| 19880173 |
Fedeli D, Carloni M, Falcioni G: Oxidative damage in trout erythrocyte in response to "in vitro" copper exposure. Mar Environ Res. 2010 Apr;69(3):172-7. Epub 2009 Oct 9.
The oxidative action of copper on different trout Oncorhynchus mykiss erythrocyte components was studied. The results indicate that: --cupric ions differently influence the oxidative status of two trout hemoglobin components I and IV (HbI and HbIV) having different structural and functional properties; --reactive oxygen species (ROS) production associated with hemoglobins autoxidation is not influenced by the presence of copper sulfate; --the susceptibility to hemolysis increases in the presence of copper only when the erythrocyte suspension is incubated in air; the effect of copper is almost absent for carbon monoxide-saturated erythrocyte suspensions; --DNA damage due to copper was not observed in our experimental conditions. The data obtained are important for the analysis of the environmental risks produced by copper on fish. |
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