| 12729008 |
Arai H, Uchida K, Fukunaga K, Nagasaka Y, Mohri S, Furumoto H, Kuramitsu Y, Nakamura K: Effect of alpha-tocopherol on the oxidative modification of apolipoprotein E in human very-low-density lipoprotein. Biosci Biotechnol Biochem. 2003 Feb;67(2):402-5.
The oxidative modification of apolipoprotein (apo) E and lipid peroxidation in human very-low-density lipoprotein (VLDL) induced by peroxynitrite and cupric ions in vitro were strongly suppressed by enrichment with alpha-tocopherol (alpha-Toc; 170 microM). Alpha-Toc also suppressed the decrease in the heparin-binding activity of apoE in the VLDL oxidation. These results suggest that alpha-Toc protected apoE in VLDL from oxidative stress. |
2(0,0,0,2) |