Protein Information

ID 4647
Name glycine receptor beta subunit
Synonyms GLRB; Glycine receptor 58 kDa subunit; Glycine receptor beta; Glycine receptor beta subunit; Glycine receptor subunit beta; Glycine receptor subunit beta precursor; Glycine receptor 58 kDa subunits; Glycine receptor betas…

Compound Information

ID 336
Name strychnine
CAS strychnidin-10-one

Reference

PubMed Abstract RScore(About this table)
18553216 Shen W, Jiang Z, Li B: Glycine input induces the synaptic facilitation in salamander rod photoreceptors. J Biomed Sci. 2008 Nov;15(6):743-54. Epub 2008 Jun 16.
Glycinergic synapses in photoreceptors are made by centrifugal feedback neurons in the network, but the function of the synapses is largely unknown. Here we report that glycinergic input enhances photoreceptor synapses in amphibian retinas. Using specific antibodies against a glycine transporter (GlyT2) and glycine receptor beta subunit, we identified the morphology of glycinergic input in photoreceptor terminals. Electrophysiological recordings indicated that 10 muM glycine depolarized rods and activated voltage-gated Ca (2+) channels in the neurons. The effects facilitated glutamate vesicle release in photoreceptors, meanwhile increased the spontaneous excitatory postsynaptic currents in Off-bipolar cells. Endogenous glycine feedback also enhanced glutamate transmission in photoreceptors. Additionally, inhibition of a Cl (-) uptake transporter NKCC1 with bumetanid effectively eliminated glycine-evoked a weak depolarization in rods, suggesting that NKCC1 maintains a high Cl (-) level in rods, which causes to depolarize in responding to glycine input. This study reveals a new function of glycine in retinal synaptic transmission.
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