| 4060158 |
Singh SV, Awasthi YC: Inhibition of human glutathione S-transferases by 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T). Toxicol Appl Pharmacol. 1985 Nov;81(2):328-36.
The phenoxyacid herbicides, 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T), inhibit all known isoenzymes of human liver and erythrocyte glutathione (GSH) S-transferase. However, the maximal inhibition and the I50 values vary significantly for different isoenzymes. GSH peroxidase II activity of GSH S-transferases is also inhibited by both these compounds. These studies suggest that the effect of these compounds on human GSH S-transferases is significantly different from that reported for rat liver enzymes. |
31(0,1,1,1) |